Требования к результатам лечения

Оптимальным результатом проведенного лечения может считаться клиническое излечение (регресс ≥90% проявлений от исходного уровня) или клиническая ремиссия (регресс клинических проявлений на 75–90%).

Тактика при отсутствии эффекта от лечения

При отсутствии эффекта от лечения наружными ретиноидами, бензоила пероксида или азелаиновой кислотой при легком течении папулопустулезных акне показана терапия комбинированными препаратами (адапален+бензоила пероксид) или системная терапия антибактериальными препаратами в сочетании с адапаленом.

При отсутствии эффекта от антибактериальной терапии в сочетании с адапаленом, комбинацией адапалена с бензоила пероксидом или азелаиновой кислотой при среднетяжелых папулопустулезных/умеренных узловатых акне показан системный изотретиноин.

ПРОФИЛАКТИКА

Методов профилактики не существует.

СПИСОК ЛИТЕРАТУРЫ

1. Gollnick H., Cunliffe W., Berson D. et al. Management of acne: a report from a Global Alliance to improve outcomes in acne. J Am Acad Dermatol 2003; 49 (Suppl.1): S1–37.

2. Webster G.F., Graber E.M. Antibiotic treatment for acne vulgaris. Semin Cutan Med Surg 2008; 27 (3): 183–187.

3. Kircik L.H. Doxycycline and minocycline for the management of acne: a review of efficacy and safety with emphasis on clinical implications. J Drugs Dermatol 2010; 9 (11): 1407–1411.

4. Amin K., Riddle C.C., Aires D.J., Schweiger E.S. Common and alternate oral antibiotic therapies for acne vulgaris: a review. J Drugs Dermatol 2007; 6 (9): 873–880.

5. Maibach H. Second-generation tetracyclines, a dermatologic overview: clinical uses and pharmacology. Cutis 1991; 48 (5): 411–417.

6. Самцов А.В. Акне и акнеиформные дерматозы. Монография – М.: OOO «ЮТКОМ», 2009. – 208 с.: ил.

7. Krunic A., Ciurea A., Scheman A. et al. Efficacy and tolerance of acne treatment using both spironolactone and a combined contraceptive containing drospirenone. J Am Acad Derm 2008; 58: 60–62.

8. Koltun W., Maloney J.M., Marr J., Kunz M. Treatment of moderate acne vulgaris using a combined oral contraceptive containing ethinylestradiol 20 μg plus drospirenone 3mg administered in a 24/4 regimen: a pooled analysis. Eur J Obstet Gynecol Reprod Biol 2011; 155 (2): 171–175.

9. Lucky A.W., Koltun W., Thiboutot D. et al. A combined oral contraceptive containing 3-mg drospirenone/ 20-microg ethinyl estradiol in the treatment of acne vulgaris: a randomized, double-blind, placebo-controlled study evaluating lesion counts and participant self-assessment. Cutis 2008; 82 (2): 143–150.

10. Frangos J., Alavian C., Kimball A. Acne and oral contraceptives: Update on women’s health screening guidelines. J Am Acad Dermatol 2008; 58: 781–786.

11. Thiboutot D., Gollnick H. New insights into the management of acne: an update from the Global Alliance to improve outcomes in acne group.J Am Acad Dermatol 2009; 60: 1–50.

12. Dreno B., Layton A., Zouboulis C. et al. Adult female acne:a new paradigm. J Eur Acad Dermatol Venereol 2013; 27: 1063–1070.

13. Cunliffe W.J., van de Kerkhof P.C., Caputo R. et al. Roaccutane treatment guidelines: results of an international survey. Dermatology 1997; 194 (4): 351–357.

14. Peck G.L., Olsen T.G., Butkus D. et al. Isotretinoin versus placebo in the treatment of cystic acne. A randomized double-blind study. J Am Acad Dermatol 1982; 6: 735–745.

15. Strauss J.S., Rapini R.P., Shalita A.R. et al. Isotretinoin therapy for acne: results of a multicenter dose-response study. J Am Acad Dermatol 1984; 10: 490–496.

16. Cunliffe W.J., Poncet M., Loesche C., Verschoore M. A comparison of efficacy and tolerability of adapalene 0,1% gel versus tretinoin 0,025% gel in patients with acne vulgaris: a meta-analysis of five randomized trial. Br J Dermatol 1998; 139 (Suppl. 52): 48–56.

17. Millikan L.E. Pivotal clinical trials of adapalene in the treatment of acne J Eur Acad Dermatol Venereol 2001; 15 (Suppl 3): 19–22.

18. Waugh J., Noble S., Scott L.J. et al. Adapalene: a review of its use in the treatment of acne vulgaris. Drugs 2004; 64 (13): 1465–1478.

19. Lucky A., Jorizzo J.L., Rodriguez D. et al. Efficacy and tolerance of adapalene cream 0,1% compared with its cream vehicle for the treatment of acne vulgaris. Cutis 2001; 68: 34–40.

20. Cunliffe W.J. Caputo R., Dreno B. et al. Clinical efficacy and safety comparison of adapalene gel and tretinoin gel in the treatment of acne vulgaris: Europe and U.S. multicenter trials. J Am Acad Dermatol 1997; 36 (6Pt2): S126–134.

21. Cunliffe W.J., Danby F.W., Dunlap F. et al. Randomised controlled trial of the efficacy and safety of adapalene gel 0,1% and tretinoin cream 0,05% in patients with acne vulgaris. Eur J Dermatol 2002; 12: 350–354.

22. Thiboutot D.M., Shalita A.R., Yamauchi P.S. et al. Adapalene gel, 0.1%, as maintenance therapy for acne vulgaris: a randomized, controlled, investigator-blind follow-up of a recent combination study. Arch Dermatol 2006; 142 (5): 597–602.

23. Cook-Bolden F. Subject Preferences for acne treatments containing adapalene gel 0,1%:results of the MORE trial. Cutis 2006; 78 (1 Suppl): 26–33.

24. Gold L.S. The MORE trial: effectiveness of adapalene gel 0,1% in real-world dermatology practices. Cutis 2006; 78 (1 Suppl): 12–18.

25. Gollnick H.P., Graupe K., Zaumseil R.P. [Azelaic acid 15% gel in the treatment of acne vulgaris. Combined results of two double-blind clinical comparative studies. J Dtsch Dermatol Ges 2004; 2: 841–847.

26. Hjorth N., Graupe K. Azelaic acid for the treatment of acne. A clinical comparison with oral tetracycline. Acta Derm Venereol Suppl (Stockh) 1989; 143: 45–48.

27. Graupe K., Cunliffe W.J., Gollnick H.P., Zaumseil R.P. Efficacy and safety of topical azelaic acid (20 percent cream): an overview of results from European clinical trials and experimental reports. Cutis 1996; 57: 20–35.

28. Katsambas A., Graupe K, Stratigos J. Clinical studies of 20% azelaic acid cream in the treatment of acne vulgaris. Comparison with vehicle and topical tretinoin. Acta Derm Venereol Suppl (Stockh) 1989; 143: 35–39.

29. Cunliffe W.J., Holland K.T. Clinical and laboratory studies on treatment with 20% azelaic acid cream for acne. Acta Derm Venereol Suppl (Stockh) 1989; 143: 31–34.

30. Gollnick H.P., Graupe K., Zaumseil R.P. Comparison of combined azelaic acid cream plus oral minocycline with oral isotretinoin in severe acne. Eur J Dermatol 2001; 11: 538–544.

31. Sagransky M., Yentzer B.A., Feldman S.R. Benzoyl peroxide: a review of its current use in the treatment of acne vulgaris. Expert Opin Pharmacother 2009; 10 (15): 2555–2562.

32. Hughes B.R., Norris J.F., Cunliffe W.J. A double-blind evaluation of topical isotretinoin 0.05%, benzoyl peroxide gel 5% and placebo in patients with acne. Clin Exp Dermatol 1992; 17 (3): 165–168.

33. Dunlop K.J., Barnetson R.S. A comparative study of isolutrol versus benzoyl peroxide in the treatment of acne. Australas J Dermatol 1995; 36 (1): 13–15.

34. Borglund E., Kristensen B., Larsson-Stymne B. et al. Topical meclocyclinesulfosalicylate, benzoyl peroxide, and a combination of the two in the treatment of acne vulgaris. Acta Derm Venereol 1991; 71 (2): 175–178.

35. Swinyer L.J., Baker M.D., Swinyer T.A. Mills O.H. Jr. A comparative study of benzoyl peroxide and clindamycin phosphate for treating acne vulgaris. Br J Dermatol 1988; 119 (5): 615–622.

36. Tucker S.B., Tausend R., Cochran R., Flannigan S.A. Comparison of topical clindamycin phosphate, benzoyl peroxide, and a combination of the two for the treatment of acne vulgaris. Br J Dermatol 1984; 110 (4): 487–492.

37. Burke B., Eady E.A., Cunliffe W.J. Benzoyl peroxide versus topical erythromycin in the treatment of acne vulgaris.Br J Dermatol. 1983; 108 (2): 199–204.

38. Lassus A. Local treatment of acne. A clinical study and evaluation of the effect of different concentrations of benzoyl peroxide gel. Curr Med Res Opin 1981; 7 (6): 370–373.

39. Cunliffe W.J., Holland K.T. The effect of benzoyl peroxide on acne. Acta Derm Venereol 1981; 61 (3): 267–269.

40. Prince R.A., Harris J.M., Maroc J.A. Comparative trial of benzoyl peroxide versus benzoyl peroxide with urea in inflammatory acne. Cutis 1982; 29 (6): 638–640, 644–645.

41. Schutte H., Cunliffe W.J., Forster R.A. The short-term effects of benzoyl peroxide lotion on the resolution of inflamed acne lesions. Br J Dermatol 1982; 106 (1): 91–94.

42. Norris J.F., Hughes B.R., Basey A.J., Cunliffe W.J. A comparison of the effectiveness of topical tetracycline, benzoyl-peroxide gel and oral oxytetracycline in the treatment of acne. Clin Exp Dermatol 1991; 16 (1): 31–33.

43. Cunliffe W.J., Burke B., Dodman B. Chloramphenicol and benzoyl peroxide in acne. A double-blind clinical study. Practitioner 1980; 224 (1347): 952–954.

44. Lyons R.E. Comparative effectiveness of benzoyl peroxide and tretinoin in acne vulgaris. Int J Dermatol 1978; 17 (3): 246–251.

45. Hare P.J. Benzoyl peroxide gel compared with retinoic acid in acne vulgaris. Br J Clin Pract 1975; 29 (3): 63–66.

46. Ede M.A double-blind, comparative study of benzoyl peroxide, benzoyl peroxide-chlorhydroxyquinoline, benzoyl peroxide-chlorhydroxyquinoline-hydrocortisone, and placebo lotions in acne. Curr Ther Res Clin Exp 1973; 15 (9): 624–629.

47. Shahlita A.R., Smith E.B., Bauer E. Topical erythromycin v clindamycin therapy for acne. A multicenter, double-blind comparison. Arch Dermatol 1984; 120 (3): 351–355

48. Kuhlman D.S., Callen J.P. A comparison of clindamycin phosphate 1 percent topical lotion and placebo in the treatment of acne vulgaris. Cutis 1986; 38 (3): 203–206.

49. Del Rosso J.Q., Schmidt N.F. A review of the anti-inflammatory properties of clindamycin in the treatment of acne vulgaris. Cutis 2010; 85 (1): 15–24.

50. Katsambas A., Towarky A.A., Stratigos J. Topical clindamycin phosphate compared with oral tetracycline in the treatment of acne vulgaris. Br J Dermatol 1987; 116 (3): 387–391.

51. Keating G.M. Adapalene 0.1%/benzoyl peroxide 2.5% gel: a review of its use in the treatment of acne vulgaris in patients aged ≥ 12 years. Am J Clin Dermatol 2011; 12 (6): 407–420.

52. Eichenfield L.E., Jorizzo J.L., Dirschka T. et al. Treatment of 2,453 acne vulgaris patients aged 12–17 years with the fixed-dose adapalene-benzoyl peroxide combination topical gel: efficacy and safety. J Drugs Dermatol 2010; 9 (11): 1395–1401.

53. Gold L.S., Tan J., Cruz-Santana A. et al. A North American study of adapalene-benzoyl peroxide combination gel in the treatment of acne. Cutis 2009; 84: 110–116.

54. Tan J., Gollnick H.P., Loesche C. et al. Synergistic efficacy of adapalene 0.1%-benzoyl peroxide 2.5% in the treatment of 3855 acne vulgaris patients. J Dermatol Treat 2011; 22 (4): 197–205.

55. Gollnick H.P., Draelos Z., Glenn M.J. et al. Adapalene–benzoyl peroxide, a unique fixed-dosecombination topical gel for the treatment of acne vulgaris:a transatlantic, randomized, double-blind, controlled study in 1670 patients.Br J Dermatol 2009; 161 (5):1180–1189.

56. Feldman S.R., Tan J., Poulin Y. et al. The efficacy of adapalene-benzoyl peroxide combination increases with number of acne lesions. J Am Acad Dermatol 2011; 64 (6): 1085–1091.

57. Pariser D.M., Westmoreland P., Morris A. et al. Long-term safety and efficacy of a unique fixed-dose combination gel of adapalene 0.1% and benzoyl peroxide 2.5% for the treatment of acne vulgaris. J Drugs Dermatol 2007; 6 (9): 899–905.

58. Thiboutot D.M., Weiss J., Bucko A. et al. Adapalene-benzoyl peroxide, a fixed-dosecombination for the treatment of acne vulgaris: Results of a multicenter, randomized double-blind, controlled study. J Am Acad Dermatol 2007; 57: 791–799.

59. Troielli P.A., Asis B., Bermejo A. et al. Community study of fixed-combination adapalene 0.1% and benzoyl peroxide 2.5% in acne. Skinmed 2010; 8 (1): 17–22.

60. Poulin Y. A 6-month maintenance therapy with adapalene-benzoyl peroxide gel prevents relapse and continuously improves efficacy among patients with severe acne vulgaris: results of a randomized controlled trial. Br J Dermatol 2011; 164: 1376–1382.

61. Thiboutot D., Gollnick H., Bettoli V. et al. New insights into the management of acne: an update from the Global Alliance to Improve Outcomes in Acne Group. J Am Acad Dermatol 2009; 60: S1–50.

62. Nast A., Dreno B., Bettoli V. et al. European evidence-based (S3) guidelines for the treatment of acne. J Eur Acad Dermatol Venereol 2012; 26 (Suppl.1): 1–29.

63. Wolf J.E., Kaplan D., Kraus S.J. et al. Efficacy and tolerability of combined topical treatment of acne vulgaris with adapalene and clindamycin: a multicenter, randomized, investigator-blinded study. J Am Acad Dermatol 2003; 49 (3 Suppl): S211–217.

64. Zhang J.Z., Li L.F., Tu Y.T., Zheng J. A successful maintenance approach in inflammatory acne with adapalene gel 0.1% after an initial treatment in combination with clindamycin topical solution 1% or after monotherapy with clindamycin topical solution 1%. J Dermatolog Treat 2004; 15 (6): 372–378.

65. Campbell J.L. Jr. A comparative review of the efficacy and tolerability of retinoid-containing combination regimens for the treatment of acne vulgaris. J Drugs Dermatol 2007; 6 (6): 625–629.

66. Weiss J.S., Shavin J.S. Topical retinoid and antibiotic combination therapy for acne management. J Drugs Dermatol 2004; 3 (2): 146–154.

67. Wolf JE Jr. Maintenance therapy for acne vulgaris: the fine balance between efficacy, cutaneous tolerability, and adherence. Skinmed. 2004 Jan-Feb;3(1):23-6.

68. Katsambas A.D., Katoulis A.C., Stavropulos P. Acne neonatorum: a study of 22 cases. Int J Dermatol 1999; 38 (2): 128–130.

69. Eichenfield L.F., Krakowski A.C., Piggott C. et al. Evidence-based recommendations for the diagnosis and treatment of pediatric acne. Pediatrics 2013; 131: 163–186.

70. Cantatore-Francis J.L., Glick S.A. Childhood acne: evaluation and management. Dermatol Ther 2006; 19 (4): 202–209.

71. Eichenfield L.F., Fowler J.F. Jr, Friedlander S.F. et al. Diagnosis and evaluation of acne. Semin Cutan Med Surg 2010; 29 (2 Suppl 1): 5–8.

72. Scheinfeld N. Epiduo (adapalene 0,1% and benzoyl peroxide 2<5%) approval in children 9 years and older. Skinmed 2013; 11 (5): 295–296.

73. Lee K.C., Lio P.A. Evidence-based recommendations for the diagnosis and treatment of paediatric acne. Arch Dis Child Educ Pract Ed 2014; 99: 135–137.

Наши рекомендации