Additional information about the 2008 WHO classification.

Lymphoma Classification

Many classification systems have been used over the years. Presented here is only the current 2008 WHO classification system. Developed in 2008 by the WHO, and adopted by most haematologists/oncologists in 2009 it represents the latest update. There is a link at the bottom of this page to older systems.

WHO classification.

Mature B-cell neoplasms

· Chronic lymphocytic leukemia/small lymphocytic lymphoma

· B-cell prolymphocytic leukemia

· Hairy cell leukemia

· Splenic marginal zone lymphoma

Additional information about the 2008 WHO classification. - student2.ru Splenic lymphoma/leukemia, unclassifiable

Additional information about the 2008 WHO classification. - student2.ru Splenic diffuse red pulp small B-cell lymphoma*

Additional information about the 2008 WHO classification. - student2.ru Hairy cell leukemia-variant*

· Lymphoplasmacytic lymphoma

Additional information about the 2008 WHO classification. - student2.ru Waldenström macroglobulinemia

· Heavy chain diseases

Additional information about the 2008 WHO classification. - student2.ru Alpha heavy chain disease

Additional information about the 2008 WHO classification. - student2.ru Gamma heavy chain disease

Additional information about the 2008 WHO classification. - student2.ru Mu heavy chain disease Plasma cell myeloma

· Solitary plasmacytoma of bone

· Extraosseous plasmacytoma

· Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)

· Nodal marginal zone B-cell lymphoma (MZL)

Additional information about the 2008 WHO classification. - student2.ru Pediatric type nodal MZL

· Follicular lymphoma

Additional information about the 2008 WHO classification. - student2.ru Pediatric type follicular lymphoma

· Primary cutaneous follicle center lymphoma

· Mantle cell lymphoma

· Diffuse large B-cell lymphoma (DLBCL), not otherwise specified

Additional information about the 2008 WHO classification. - student2.ru T cell/histiocyte rich large B-cell lymphoma

Additional information about the 2008 WHO classification. - student2.ru DLBCL associated with chronic inflammation

Additional information about the 2008 WHO classification. - student2.ru Epstein-Barr virus (EBV)+ DLBCL of the elderly

· Lymphomatoid granulomatosis

· Primary mediastinal (thymic) large B-cell lymphoma

· Intravascular large B-cell lymphoma

· Primary cutaneous DLBCL, leg type

· ALK+ large B-cell lymphoma

· Plasmablastic lymphoma

· Primary effusion lymphoma

· Large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease

· Burkitt lymphoma

· B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma

· B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma

· Hodgkin Lymphoma

· Nodular lymphocyte-predominant Hodgkin lymphoma

· Classical Hodgkin lymphoma

Additional information about the 2008 WHO classification. - student2.ru Nodular sclerosis classical Hodgkin lymphoma

Additional information about the 2008 WHO classification. - student2.ru Lymphocyte-rich classical Hodgkin lymphoma

Additional information about the 2008 WHO classification. - student2.ru Mixed cellularity classical Hodgkin lymphoma

Additional information about the 2008 WHO classification. - student2.ru Lymphocyte-depleted classical Hodgkin lymphoma

Mature T-cell neoplasms

T-cell prolymphocytic leukemia
T-cell large granular lymphocytic leukemia
Chronic lymphoproliferative disorder of NK-cells*
Aggressive NK cell leukemia Systemic EBV+ T-cell lymphoproliferative disease of childhood (associated with chronic active EBV infection)
Hydroa vacciniforme-like lymphoma
Adult T-cell leukemia/lymphoma
Extranodal NK/T cell lymphoma, nasal type
Enteropathy-associated T-cell lymphoma
Hepatosplenic T-cell lymphoma
Subcutaneous panniculitis-like T-cell lymphoma
Mycosis fungoides Sézary syndrome
Primary cutaneous CD30+ T-cell lymphoproliferative disorder

Lymphomatoid papulosis

Primary cutaneous anaplastic large-cell lymphoma

Primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma*
Primary cutaneous gamma-delta T-cell lymphoma
Primary cutaneous small/medium CD4+ T-cell lymphoma*
Peripheral T-cell lymphoma, not otherwise specified
Angioimmunoblastic T-cell lymphoma
Anaplastic large cell lymphoma (ALCL),
ALK+ Anaplastic large cell lymphoma (ALCL), ALK–*

*These represent provisional entities or provisional subtypes of other neoplasms.

Source information from Blood Journal and the 2009 ASH education series

Additional information about the 2008 WHO classification.

The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications

The chart below outlines what types of lymphoma correspond with what stage of B-cell development.

Indolent / Aggressive classification

The following table classifies the lymphoproliferative disorders according to whether they belong to the indolent (slow growing) or aggressive subtype. This includes lymphomas, leukaemias, and myelomas. This is based on the previous REAL/WHO classification system not the current 2008 WHO system.

Additional information about the 2008 WHO classification. - student2.ru

Indolent lymphoma/leukemia

A. Follicular lymphoma (follicular small cleaved cell [grade 1], follicular mixed small cleaved and large cell [grade 2], diffuse small cleaved cell)
B. Chronic lymphocytic leukemia/small lymphocytic lymphoma
C. Lymphoplasmacytic lymphoma (Waldenstrom's macroglobulinemia)
D. Extranodal marginal zone B-cell lymphoma (MALT lymphoma
E. Nodal marginal zone B-cell lymphoma (monocytoid B-cell lymphoma)
F. Splenic marginal zone lymphoma (splenic lymphoma with villous lymphocytes)
G. Hairy cell leukemia
H. Mycosis fungoides/Sezary syndrome
I. T-cell granular lymphocytic leukemia
J. Primary cutaneous anaplastic large cell lymphoma/lymphomatoid papulosis (CD30+)
K. Nodular lymphocyte predominant Hodgkin's lymphoma